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http://projects.csail.mit.edu/courseware/?term=essay-on-good-education essay on good education 6%). Similar findings have been reported in younger patients, making chop plus rituximab first-line therapy for advancedstage diffuse, aggressive nhl (table 97–9). »» special populations there are histologic subtypes of diffuse, aggressive nhl that respond less well to treatment with conventional regimens such as chop. Burkitt lymphoma, lymphoblastic lymphoma, mantle cell lymphoma, and primary cns lymphoma are examples of disease that benefit from more intensive therapy. Regimens such as hyper-cvad, which alternate cycles of hyperfractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone with high-dose cytarabine and methotrexate, may be substituted for chop. Patients with cns nhl have disease that is poorly responsive to therapy because of inadequate penetration of standard doses of chemotherapy across the blood–brain barrier. High-dose methotrexate, ranging from 2500 to 8000 mg/m2 is a mainstay of therapy. Treatment may also include intrathecal chemotherapy. Drugs that are commonly instilled intrathecally include table 97–9  treatment regimens for diffuse, aggressive nhl rchop—every 21 daysa epoch-rituximab—every 21 days rituximab 375 mg/m2 iv, day 1 etoposide 50 mg/m2/day civi days 1–4 prednisone 60 mg/m2/day po, days 1–5 vincristine 0. 4 mg/m2/day civi days 1–4 cyclophosphamide 750 mg/m2 iv day 5 doxorubicin 10 mg/m2/day civi days 1–4 rceop—every 21 daysb rituximab 375 mg/m2 iv, day 1 cyclophosphamide 750 mg/m2 iv, day 1 etoposide 50 mg/m2 iv, day 1 etoposide 100 mg/m2 po days 2–3 vincristine 1. 4 mg/m2 iv, day 1 prednisone 100 mg/day po, days 1–5 cnop-rituximab—every 21 daysb rituximab 375 mg/m2 iv, day 1 cyclophosphamide 750 mg/m2 iv, day 1 mitoxantrone 10 mg/m2 iv, day 1 vincristine 1. 4 mg/m2 iv, day 1 prednisone 100 mg/day po, days 1–5 hyper-cvad part a. The following drugs given on course 1, 3, 5 and 7 cyclophosphamide 300 mg/m2 iv every 12 hours, days 1–3 (with mesna) doxorubicin 50 mg/m2 iv, day 1 vincristine 1. 4 mg/m2 iv, days 1,11 dexamethasone 40 mg/day po, days 1–4 and 11–14 methotrexate 15 mg intrathecal, day 2 cytarabine 30 mg intrathecal, day 2 hydrocortisone 15 mg intrathecal, day 2 part b. The following drugs are given on courses 2, 4, 6, and 8 methotrexate 1000 mg/m2 iv over 24 hours, day 1 cytarabine 3000 mg/m2 iv every 12 hours, days 2 and 3 leucovorin 25 mg iv × 1. Then 25 mg po every 6 hours for seven doses methotrexate 15 mg intrathecal, day 2 bendamustine/rituximab—every 28 daysa eshap etoposide 40 mg/m2 iv per day continuous infusion, days 1–4 cisplatin 25 mg/m2 iv per day continuous infusion, days 1–4 cytarabine 2000 mg/m2 iv × 1, day 5 methylprednisone 250 mg iv every 12 hours, days 1–4 dhap dexamethasone 40 mg po or iv daily, days 1–4 cisplatin 100 mg/m2 iv continuous infusion, day 1 cytarabine 2000 mg/m2 iv every 12 hours for two doses on day 2 ice etoposide 100 mg/m2 iv daily, days 1–3 carboplatin auc 5 (maximum dose, 800 mg) iv, day 2 ifosfamide 5000 mg/m2 iv continuous infusion × 1 on day 2 (with 100% replacement with mesna) refer to table 97–8 for regimen. Data is limited, use only for patients who are unable to receiving an anthracycline. Auc, area under the curve. Civi, continuous intravenous infusion. Iv, intravenous. Po, oral.

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https://graduate.uofk.edu/user/diploma.php?sep=argumentative-essay-helpful-phrases argumentative essay helpful phrases Leverich gs, altshuler ll, frye ma, et al. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am j psychiatry. 2006;163:232–239. 32. Thomas t, stansifer l, findling rl. Psychopharmacology of pediatric bipolar disorders in children and adolescents. Pediatr clin north am. 2011;58:173–187. 33. Pringsheim t, lam d, ching h, et al. Metabolic and neurological complications of second-generation antipsychotic use in children. A systematic review and meta-analysis of randomized controlled trials. Drug saf. 2011;34:651–668. 34. Lala sv, sajatovic m. Medical and psychiatric comorbidities among elderly individuals with bipolar disorder. A literature review. J geriatr psychiatry neurol. 2012;25:20–25. 35. Yonkers ka, vigod s, ross le. Diagnosis, pathophysiology, and management of mood disorders in pregnant and postpartum women. Obstet gynecol. 2011;117:961–977. 36. Deligiannidis km, byatt n, freeman mp. Pharmacotherapy for mood disorders in pregnancy. A review of pharmacokinetic changes and clinical recommendations for therapeutic drug monitoring. J clin psychopharmacol. 2014;34:244–255.

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