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http://cs.gmu.edu/~xzhou10/semester/honors-thesis-unl.html honors thesis unl ) table 96–1  drugs used in cml  (continued) drug adverse effects comments renal dosing hepatic dosing bosutinib (bosulif) diarrhea, nausea vomiting, thrombocytopenia, neutropenia, increased liver function tests, fluid retention dasatinib (sprycel) thrombocytopenia, neutropenia, headache, rash, edema, pleural effusions dose. 500 mg po once daily crcl 30–50 ml/min any baseline liver dose may be increased to 600 mg po once (0. 50–0. 83 ml/s). 500 mg impairment. 200 mg daily if complete hematologic response daily and may decrease daily not seen at 8 weeks or complete to 400 mg if cannot cytogenetic response by 12 week tolerate take with food crcl < 30 ml/min drug interactions. Metabolized by cyp 3a4. (0. 50 ml/s). 300 mg inhibitor and substrate of p-glycoprotein daily dose. 100 mg po once daily for chronic no reductions no reductions phase cml or 140 mg po daily for accelerated phase or blast crisis avoid concomitant medications that prolong the qt-interval. Low levels of potassium and magnesium should be corrected before initiating therapy drug interactions. Metabolized by cyp 3a4 dasatinib exhibits ph-dependent absorption. Avoid medications that alter gastric ph (eg, h2 antagonists and ppis) (continued ) 1420  section 16  |  oncologic disorders table 96–1  drugs used in cml  (continued) drug imatinib mesylate (gleevec, sti 571) adverse effects neutropenia, thrombocytopenia, diarrhea, rash, nausea, edema, fatigue, arthralgias, myalgias, headache, increased liver function tests, congestive heart failure (rare) nilotinib (tasigna) thrombocytopenia, neutropenia, elevated bilirubin, elevated serum lipase comments renal dosing dose range. 400–800 mg po per day crcl 20–39 ml/min depending on phase (0. 33–0. 66 ml/s). 50% take with meals and a full glass of water reduction in dose drug interactions. Metabolized by cyp 3a4. Crcl < 20 ml/min weak inhibitor of cyp 2d6 and 2c9 (0.

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