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venice description essay Respiratory disorders i 385 b. Optimal pac02 varies according to disease state. For very immature infants or infants with air leak, a pac02 of 50 to 60 mm hg may be tolerated to minimize ventilator-induced lung injury, provided ph can be maintained >7.20 to 7.25. V. Disease states a. Effects of diseases. Respiratory failure can result from numerous illnesses through a variety of pathophysiologic mechanisms. Optimal ventilatory strategy must take into account the pathophysiology, expected time course, and particular vulnerabilities of the patient. B. Pulmonary mechanics influence the ventilator strategy selected. 1. Compliance is the stiffness or distensibility of the lung and chest wall.

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