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http://www.cs.odu.edu/~iat/papers/?autumn=tips-for-helping-students-with-homework tips for helping students with homework Race, gender, and age confer different rates. The annual incidence rate per 100,000 is 1 for blacks, 4 for hispanics, and 25 for non-hispanic whites. 3 while women are more likely to develop melanoma than men before the age of 50, the converse occurs after the age of 50, with men having double the incident rate at age 65 and triple the rate at age 80 compared to women. 4 the change in risk may be due to the different level of sun exposure, be it occupational or recreational, through the lifetime of a particular sex. Even though incidence rates have significantly increased in the last 30 years, the rate among young age groups has leveled off. The incidence rate for men and women 50 years of age or older increased 2. 6% per year from 2007 to 2011 but was relatively stable for those below age 50. Risk factors environmental the risk factors for developing mm can be categorized as environmental factors and host factors. Exposure to ultraviolet radiation (uvr) from the sun is recognized as one of the primary triggers for skin carcinogenesis. Uv radiation (specifically uvb) is absorbed by dna in the cells in the epidermal layer and may induce dna damage. Gene mutations, such as uvrinduced mutation to the p53 tumor suppressor gene, may occur, resulting in dysregulation of apoptosis, expansion of mutated keratinocytes, and initiation of skin cancer. 2 other mechanisms of uv radiation–induced dna damage include the generation of reactive oxygen species, which create breaks in dna, leading to genetic mutations and skin cancer. 2 it is estimated that 65% to 90% of mms are attributable to uv exposure, particularly when a person has a history of intense and blistering sunburns in childhood. If a person experienced more than one severe sunburn in childhood, the risk of developing melanoma is increased twofold. 2 exposure to sources of artificial uv radiation such as tanning beds has also been linked to increased risk of skin cancer. 2 host factors host risk factors for developing mm include individuals with phenotypic characteristics of red hair, light skin, blue eyes, sun sensitivity, and freckling. Family history of mm in a firstdegree relative is another risk factor for developing mm, with a twofold likelihood compared with patients with no family history. 2 in individuals without a family history of mm (sporadic 1375 1376  section 16  |  oncologic disorders patient encounter, part 1 a 55-year-old woman presents to her dermatologist with a pigmented skin lesion on her left shoulder that she noticed had enlarged and changed color recently in the past few months. History. She has the lesion since youth, and it was measured at 3 mm. She noticed the change in color and size in the past few months. The woman reports being a “sun worshiper” all her life. She spends her weekends outdoors or at the pool and vacations at the beach. She notes that she burns initially and then eventually tans with excessive freckling. She reports using an indoor tanning bed 3 to 5 days a week for the past 20 years. She does not use sunscreen or practice sun protection measures. What are this patient’s risk factors for developing malignant melanoma?.

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